1) Preparation of a Z-Iodoalkene through Stork-Zhao-Wittig Olefination, Stereo-retentive Lithium-iodine Exchange and Z-Boronic acid Pinacol Ester Synthesis
Mathieu A. Morin, Samantha Rohe, Cecile Elgindy, and Michael S. Sherburn
Org. Synth. 2020, 97, 217-231.
Checked by Alexander Preinfalk, Martin Berger, and Nuno Maulide
2) Palladium-Catalyzed Acetylation of Arylbromides
Milauni M. Mehta, Andrew V. Kelleghan, and Neil K. Garg
Checked by Martina Drescher, Daniel Kaiser, Nuno Maulide, Zach Ariki, Yuki Maekawa, and Cathleen Crudden
3) Cu-catalyzed Allylic Perfluoroalkylation of Alkenes Using Perfluoro Acid Anhydrides: Preparation of N-(5,5,5-Trifluoro-2-penten-1-yl)phthalimide
Yuma Aoki, Shintaro Kawamura, and Mikiko Sodeoka
Checked by Martina Drescher, Daniel Kaiser, and Nuno Maulide
4) Palladium-Catalyzed Hydrodefluorination of Fluoroarenes
Joseph J. Gair, Ronald L. Grey, Simon Giroux, and Michael A. Brodney
Org. Synth. 2021, 98, 131-146.
Checked by Vincent Porte, Daniel Kaiser, and Nuno Maulide
5) Synthesis of the Isocyanide Building Block Asmic, anisylsulfanylmethylisocyanide
Embarek Alwedi, Bilal Altundas, Allen Chao, Zachary L. Ziminsky, Maanasa Natrayan, and Fraser F. Fleming
Org. Synth. 2021, 98, 147-170.
Checked by Names Anthony J. Fernandes, Martina Drescher, and Nuno Maulide
6) Large-Scale Preparation of Oppolzer's Glycylsultam
Upendra Rathnayake, H. Ümit Kaniskan, Jieyu Hu, Christopher G. Parker, and Philip Garner
Org. Synth. 2021, 98, 463-490.
Checked by Bogdan R. Brutiu, Martina Drescher, Daniel Kaiser and Nuno Maulide
7) Preparation of N-Formylamides by Oxidative Cleavage of N-Acylaminoacids
Nick Kilyeni
Checked by Miran Lemmerer, Manuel Schupp, and Nuno Maulide
8) A Convenient Method for the Removal of Tetrabutylammonium Salts from Desilylation Reactions
Luca McDermott, Dominick C. Witkowski, and Neil K. Garg
Checked by Philipp Spieß, Daniel Kaiser and Nuno Maulide
9) Synthesis of Phenols from Benzoic Acids
Wenzhang Xiong, Rui Wang, Zhengqiang Liu, Feng Peng, Ralph Zhao, and Wenbo H. Liu
Org. Synth. 2023, 100, 199-217.
Checked by Martina Drescher, Saad Shaaban and Nuno Maulide
10) Preparation of Pyrylium Tetrafluoroborate (Pyry-BF4)
Alejandro Gómez-Palomino, Clément Ghiazza, Julia Busch, Lucas Wagner and Josep Cornella
Org. Synth. 2023, 100, 361-381.
Checked by Thomas Leischner, Benjamin Thomas Jones, and Nuno Maulide
11) Preparation of 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonyl fluoride (ArSO2F)
Lucas Wagner, Clément Ghiazza and Josep Cornella
Org. Synth. 2023, 100, 382-393.
Checked by Haoqi Zhang, Daniel Kaiser and Nuno Maulide
12) Synthesis of Deuterated 1H-Indole-3-carboxaldehyde via Catalytic Vilsmeier-Haack Reaction
Jing Xue, Yushan Zhang, Bing Zhong and Jin-Dong Yang
Checked by Paolo Piacentini, Omar Abdo and Nuno Maulide
13) Difluoromethylation of Phenols
Allison T. Hands, Zachary G. Walters, Jacob P. Sorrentino, and Neil K. Garg
Org. Synth. 2024, 101, 164-180.
Checked by Yi Xiao, Milos Vavrik and Nuno Maulide
14) Preparation of S-Methyl Methanethiosulfonate from Dimethyl Sulfoxide Initiated by Oxalyl Chloride
Xixuan Zhao, Shuai Peng, Hao Wang, Shuai Huang, Baoguo Sun, Hongyu Tian and Sen Liang
Org. Synth. 2024, 101, 395-409.
Checked by Roberto Tinelli, Sophie Woolford and Nuno Maulide
15) Synthesis of Borane-Ammonia and its Application in the Titanium Tetrachloride Catalyzed Reduction of Carboxylic Acids, Including N-Protected Amino Acids
Henry J. Hamann, Abdulkhaliq A. Alawaed, and P. Veeraraghavan Ramachandran
Checked by Gwyndaf A. Oliver, Konstantin Günther and Nuno Maulide
16) Preparation of 1,3-Dihydroxyphenazine
Trevor Dzwiniel, Emma Markun, James A. Kaduk, Aaron Hollas, Krzystof Pupek, and Nicholas Boaz
Checked by Uros Vezonik, Florian Doubek and Nuno Maulide
17) Large-Scale NaBr/Selectfluor Mediated Alcohol Oxidation: Conversion of (-)-Borneol into (-)-Camphor
Shyam Sathyamoorthi
Org. Synth. 2025, 102, 100-113.
Checked by Sergio Armentia Matheu, Saad Shaaban, and Nuno Maulide
18) Synthesis of gem-Difluoroalkenes through Ramberg-Bäcklund Reaction of Alkyltriflones
Motoo Ohtsuka, Yasuyo Tahara-Tezuka, Yuuki Maekawa, Cathleen M. Crudden, and Masakazu Nambo
Org. Synth. 2025, 102, 315-334.
Checked by Nikolaos Skoulikas, Lorenz Erlbacher and Nuno Maulide
19) Umpolung Synthesis of α-Bromo Secondary Amides from Unactivated Hydroxamates
Rui Wang, Hao Cao, and Wenbo H. Liu
Org. Synth. 2025, 102, 601-624.
Checked by Irmgard Tiefenbrunner, Angela Hofmeister and Nuno Maulide
20) Synthesis of Aryl Halides via a Safer Sandmeyer Reaction Protocol
Tim Schulte, Felix Waldbach, Tobias Ritter
Org. Synth. 2026, 103, 101-120.
Checking Authors Kunj Kapur, Daniya Aynetdinova, and Nuno Maulide
21) Copper-Mediated Oxidative Bromodifluoromethylation of Phenols: Preparation of Phenyl 4-(bromodifluoromethoxy) benzoate
Wen-Juan Yuan, Chao-Lai Tong, and Feng-Ling Qing
Org. Synth. 2026, 103, 192-204.
Checking Authors Uroš Vezonik, Sabela Vega-Ces, and Nuno Maulide
22) Preparation of 2-Iodoxybenzoic Acid (IBX)
Marianna C. Tonoyan, Aimee K. Long, and Neil K. Garg
Org. Synth. 2026, 103, 205-217.
Checking Authors: Milos Vavrik, Nikolaos Skoulikas, and Nuno Maulide